Stopping Depakote suddenly can cause serious problems. Depakote can cause serious side effects, including: Serious liver damage that can cause death, especially in children younger than 2 years old.
The risk of getting this serious liver damage is more likely to happen within the first 6 months of treatment. In some cases, liver damage may continue despite stopping the drug. Call your healthcare provider right away if you get any of the following symptoms: Depakote may harm your unborn baby. If you take Depakote during pregnancy for any medical condition, your baby is at risk for serious birth defects that affect the brain and spinal cord and are called spina bifida or neural tube defects.
These defects occur in 1 to 2 out of every babies born to mothers who use this medicine during pregnancy. These defects can begin in the first month, even before you know you are pregnant. Other birth defects that affect the structures of the heart, head, arms, legs, and the opening where the urine comes out urethra on the bottom of the penis can also happen.
Birth defects may occur even in children born to women who are not taking any medicines and do not have other risk factors.
Taking folic acid supplements before getting pregnant and during early pregnancy can lower the chance of having a baby with a neural tube defect. If you take Depakote during pregnancy for any medical condition, your child is at risk for having a lower IQ.
There may be other medicines to treat your condition that have a lower chance of causing birth defects and decreased IQ in your child. In most cases, this has happened during the first 6 months of treatment.
The risk is highest for children under the age of 2 years, especially those who take more than one antiseizure medication, or those who have certain medical conditions e. Children aged 3 to 10 years are also at a higher risk if they take more than one antiseizure medication. Liver function tests should take place before starting treatment with divalproex.
Your doctor may also perform liver function tests regularly to monitor the function of your liver. Serious liver problems may be preceded by symptoms such as loss of seizure control, malaise, weakness, lethargy, loss of appetite, and vomiting. People who take valproic acid should tell their doctor at once if they experience these symptoms.
Increases in the levels of ammonia in the blood, with or without lethargy or coma, have been reported and may be present despite normal liver function tests. People taking divalproex have experienced life-threatening pancreatitis inflammation of the pancreas. These cases have occurred shortly after starting the medication and after several years of taking the medication. If you experience signs of pancreatitis such as abdominal pain on the upper left side, back pain, loss of appetite, nausea, fever, chills, rapid heartbeat, or swollen abdomen contact your doctor immediately.
There is a small risk that this medication may result in thoughts of suicide. If you experience these symptoms or any other behaviour change while taking this medication, contact your doctor immediately. Family members or caregivers of people who are taking this medication should contact the person's doctor immediately if they notice unusual behaviour changes.
You may report side effects to Health Canada at Click here to view a more detailed list of Depakote side effects. If you miss a dose of Depakote Divalproex Sodium mg, take it as soon as you remember.
If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with Depakote Divalproex Sodium mg include: Low-dose aspirin, as prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention usually these dosages are milligrams per day , should be continued.
Consult your doctor or pharmacist if you are using aspirin for any reason. Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana, antihistamines such as cetirizine, diphenhydramine , drugs for sleep or anxiety such as alprazolam, zolpidem , muscle relaxants such as carisoprodol, cyclobenzaprine , and narcotic pain relievers such as codeine, hydrocodone. Check the labels on all your medicines such as allergy or cough-and-cold products because they may contain ingredients that cause drowsiness.
Ask your pharmacist about using those products safely. Depakote Divalproex Sodium mg may affect certain lab tests e. Make sure laboratory personnel and your doctors know you use Depakote Divalproex Sodium mg. Rarely, Depakote Divalproex Sodium mg has caused serious sometimes fatal liver problems, usually within the first 6 months of starting treatment.
Laboratory tests should be performed before you start treatment and periodically during treatment, especially within the first 6 months, to monitor this side effect.
The risk of serious liver problems is increased in children younger than 2 years, especially if they have an inherited metabolic disorder, severe seizure disorder with mental retardation, organic brain disease, or if they take more than one seizure medication.
Talk with the doctor about the risks and benefits of using Depakote Divalproex Sodium mg in children younger than 2 years. Due to an increased risk for liver problems, people with certain inherited metabolic disorders such as Alpers-Huttenlocher syndrome should not use Depakote Divalproex Sodium mg.
Children younger than 2 years who might have these disorders should not use Depakote Divalproex Sodium mg. Children older than 2 years who might have these disorders should be closely monitored during treatment with Depakote Divalproex Sodium mg. Talk to your doctor for details. Depakote Divalproex Sodium mg has rarely caused severe sometimes fatal disease of the pancreas pancreatitis. This may occur at any time during treatment and can quickly worsen.
Taking Depakote Divalproex Sodium mg during pregnancy can cause birth defects and may lower your child's IQ. Women of childbearing age should discuss the risks and benefits of Depakote Divalproex Sodium mg, other treatment options, and use of reliable forms of birth control with their doctor.
It may harm an unborn baby. Your doctor may start you at a lower dose of Depakote. In this study,children born to mothers who had used valproate products during pregnancy had 2. Hypoglycemia has been reported in neonates whose mothers have taken valproate during pregnancy. If clinically indicated, alternative treatment may be considered. The risk of serious liver problems is increased in children younger than divalproex years, especially if they have an inherited metabolic disorder, severe seizure disorder with mental retardation, organic brain disease, or if they sodium more than one divalproex medication. If you are planning pregnancy, become pregnant, or think you 500mg be pregnant, immediately talk to your doctor. Anyone considering prescribing Depakote or any other AED must balance the risk of suicidal thoughts or behavior with the risk of untreated illness. Eosinophilia is often present. If you notice other effects not listed above, divalproex sodium ec 500mg, contact your doctor or pharmacist. Check with your doctor if you notice any symptom that worries you while you are taking this medication. This may occur at any time during treatment and can quickly worsen. Keep all medications away from children and pets. Talk to your 500mg for details. Valproate dosage adjustment may be necessary when it is co-administered with rifampin.
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